Is It True Methadone Stays in Your System for 3 Days Only?
Question by young sexy: is it true methadone stays in your system for 3 days only?
monday will be 4 days
Best answer:
Answer by [email protected]
Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs. Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22. However, metabolism rates vary greatly between individuals, up to a factor of 100,[5][6] ranging from as few as 4 hours to as many as 130 hours,[7] or even 190 hours.[8] This variability is apparently due to genetic variability in the production of the associated enzymes CYP3A4, CYP2B6 and CYP2D6. A longer half life frequently allows for administration only once a day in heroin detoxification and maintenance programs. Patients who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[7] This can also allow lower total doses in some such patients. The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day.[citation needed]
The toxic effects of an overdose can be treated with naloxone.[9] Naloxone would problably be a second substitute to the newer, longer acting antagonist Naltrexone since Methadone’s duration is much, much longer then either heroin or other shorter-acting agonists, and the antagonist Naloxone would require several doses to keep your receptors antagonized over a long period of time.
Answer by That Dood
Opiates and opiate painkillers usually with a single dose will not stay in your system longer than 4 days, but that would be with a heavy dose so i beleive you are safe, if you have more questions like this and want immediate answers you can always check www.erowid.org for dosing information and for information on how long a drug will stay in your system from a urine analysis test
LMA MAD Nasal™ – Opiate Overdose — Dr Andrew Mason and Stephen Murrow discuss the use of LMA MAD Nasal™ as an effective treatment option for Opiate Overdose.
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